Senior Scientist - Translational Research

Vancouver, WA

Absci is a data-first AI drug creation company designing differentiated therapeutics using generative AI. Our Integrated Drug Creation platform powers cutting-edge de novo AI models and AI lead optimization models aimed at designing better biologics against difficult-to-drug targets. 

Absci is a global company with a state-of-the-art lab and headquarters in Vancouver, WA, AI Research Lab in New York City, AI Computational Center in Serbia, and Drug Creation innovation center in Switzerland. absci.com/joinus

Senior Scientist - Translational Research 

Vancouver, WA, onsite or Hybrid (50%) 

As a Senior Scientist in Translational Research at Absci, you will spearhead the design and execution of translational strategies for early-stage assets, leveraging your deep scientific knowledge and understanding of disease biology. Your role will encompass both the forward translation of preclinical experiments and the reverse translation of clinical trial insights to drive program progression.

Responsibilities: 

  • Drug Target Validation: Provide key translational insights to support drug target validation and selection, enhancing Absci’s drug creation pipeline.
  • Translational Strategy: Serve as the primary contact for the design and implementation of translational strategies based on a robust disease biology understanding.
  • Program Progression: Generate and interpret pharmacological efficacy, pharmacokinetic, safety, and toxicological data in collaboration with disease biology experts to advance programs.
  • Study Design and Execution: Design and execute translational and toxicological studies, ensuring rigorous scientific standards.
  • CRO Management: Oversee preclinical CRO activities, including project design, timelines, budgets, and deliverables.
  • Clinical Strategy Contribution: Contribute to the development of early clinical strategies by leveraging biomarker insights.
  • Interdisciplinary Collaboration: Work closely with project team members across disciplines to rapidly advance projects into clinical development.
  • Stakeholder Relationships: Build and maintain strong relationships with key external stakeholders, including investigators, Key Opinion Leaders, and health authorities.
  • Publications and Presentations: Contribute to scientific publications and patents, and present results at scientific conferences and meetings.

Qualifications:

  • Educational Background: PhD in Life Sciences (Pharmacology, Biochemistry, Biology) with 5+ years of relevant experience in drug discovery or clinical development.
  • Translational Research Experience: Proven experience in translational research and/or early clinical trials, preferably with biologics, including interactions with health authorities (e.g., IND/CTA filings).
  • Industry Expertise: Documented industry experience in translating early research into preclinical and clinical development activities, including coordination with CROs and consultants.
  • Drug Discovery Proficiency: Demonstrated track record in drug discovery with expertise in in vitro and in vivo pharmacology, biomarker identification and validation, ADME/PK, and toxicology.
  • Demonstrated alignment with Absci's core values, including a passion for innovation, belief and desire in working as one team to achieve our mission, and a commitment to excellence in all endeavors.

The salary range for this position is $127,000 - $165,000/year. Competitive equity package applies. Pay offered may vary depending on job-related knowledge, skills, and experience. In addition to equity, compensation packages include a wide range of medical, dental, vision benefits and ability to participate in our employee stock purchase plan.

Absci offers highly competitive salaries and benefits, including medical, dental, vision insurance, unlimited vacation, parental leave, breakfast and lunch for onsite employees, employee assistance program, voluntary life and disability insurance, annual bonus potential, and 401(k) with a generous company match. Legal authorization to work in the United States is required.

We seek candidates who will dive into our creative company culture that’s collaborative, multidisciplinary, and committed to a big vision for positive impact. We are defying conventions and innovating without boundaries. We are disrupting an industry with bold ideas and passionate pursuit of new possibilities. We are looking for original thinkers, creative scientists, and data-devoted gurus. Successful candidates will be excited to work in a dynamic environment and contribute as a key member of a project team. If this sounds good to you, we invite you to join us in our quest to redefine possible.

Legal authorization to work in the United States is required. Absci is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation, or any characteristic protected under applicable law. Absci will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Absci offers a dog-friendly work environment - bring your pup along for the ride.

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